A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities — and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.
The discoveries in animal models support a key role for the intestines and microbiota in the development of cardiovascular disease, said Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center.
Credit: Depositphotos_187204784_l-2015
- A high fat diet disrupts the inner workings of the gut, and this may contribute to cardiovascular disease risk, according to a recent study.
- The researchers investigated the link between greasy diets, gut microbes, and the risk of developing heart diseases in mice.
- The findings may shed light on the exact mechanism through which high fat diets increase the risk of cardiovascular diseases — and how to prevent these negative outcomes.