A high-fat diet disrupts the biology of the gut’s inner lining and its microbial communities — and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.
The discoveries in animal models support a key role for the intestines and microbiota in the development of cardiovascular disease, said Mariana Byndloss, DVM, PhD, assistant professor of Pathology, Microbiology and Immunology at Vanderbilt University Medical Center.
- A high fat diet disrupts the inner workings of the gut, and this may contribute to cardiovascular disease risk, according to a recent study.
- The researchers investigated the link between greasy diets, gut microbes, and the risk of developing heart diseases in mice.
- The findings may shed light on the exact mechanism through which high fat diets increase the risk of cardiovascular diseases — and how to prevent these negative outcomes.